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The key features for probes is that they must be an adequate size to assess the route of permeability being assessed and freely filtered into urine where they can be measured

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Tumor-associated microglia and macrophages in glioblastoma: From basic insights to therapeutic opportunities

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As such GGT plays an integral role in GSH homeostasis and has been traditionally regarded as a component of the cellular defense system against oxidative stress (Pompella et al., 2007)